Response to amphetamine

Across TCGA cell cohorts, RNA activity of the Response to amphetamine pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM200B, NWD1, and XYLT1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FAM200B grouped by Response to amphetamine-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	FAM200B →	-0.661	-0.232	.004	.002	3	3
BLOOD_Myeloma	NWD1 →	-0.023	-0.319	.006	.004	3	3
LARGE_INTESTINE	XYLT1 →	+1.310	+0.195	.002	.005	3	2
STOMACH	POLR2C →	-0.691	-0.615	<.001	.007	3	2
PANCREAS	CAPN15 →	+0.736	+0.319	.003	.003	3	2
PANCREAS	FOS →	+1.359	+0.288	.009	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FAM200B by Response to amphetamine activity — OESOPHAGUS

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