Startle response

Across TCGA patient cohorts, RNA activity of the Startle response pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPX8, PADI2, and RAB30, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Startle response activity versus GPX8 in GBM (Pearson r = -0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	GPX8 →	-0.870	-0.466	<.001	.003	3	4
BRCA	PADI2 →	-0.991	-0.189	.001	.003	3	3
BRCA	RAB30 →	+0.827	+0.221	.008	.006	3	3
BRCA	HID1 →	+1.116	+0.230	.001	.009	3	3
LSCC	LINC02043 →	-0.450	-0.333	.005	.003	3	3
BRCA	LINC00504 →	+1.104	+0.215	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001964 vs GPX8 — GBM

Explore this scatter interactively →