Startle response

Across TCGA cell cohorts, RNA activity of the Startle response pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TUBA1A, BACE1, and NRSN2, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Startle response activity versus TUBA1A in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	TUBA1A →	+1.791	+0.137	<.001	<.001	3	11
BONE	BACE1 →	+1.723	+0.258	<.001	<.001	3	10
STOMACH	NRSN2 →	+2.264	+0.160	<.001	.001	3	9
STOMACH	RECK →	+1.593	+0.134	<.001	<.001	3	8
STOMACH	DNAJB5 →	+1.224	+0.138	<.001	<.001	3	8
STOMACH	ZEB1 →	+1.997	+0.173	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001964 vs TUBA1A — UPPER_AERODIGESTIVE_TRACT

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