Startle response

Across TCGA cell cohorts, RNA activity of the Startle response pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDF, TP53I3, and MFSD2B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Startle response activity versus PDF in LUNG_NSCLC_LUSC (Pearson r = -0.88).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	PDF →	-1.133	-1.754	.007	<.001	3	3
BREAST	TP53I3 →	-2.303	-1.693	.001	<.001	3	3
BREAST	MFSD2B →	-0.343	-1.870	.004	.002	3	3
LUNG_NSCLC_LUSC	PPP6R1 →	-1.489	-1.754	.007	<.001	3	2
LUNG_NSCLC_LUSC	TASOR2 →	-1.273	-1.754	<.001	<.001	3	2
LUNG_NSCLC_LUSC	RAPGEF2 →	-1.263	-1.754	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001964 vs PDF — LUNG_NSCLC_LUSC

Explore this scatter interactively →