Blood vessel maturation

Across TCGA patient cohorts, RNA activity of the Blood vessel maturation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYH14, PPP2R5C, and ABHD4, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Blood vessel maturation activity versus MYH14 in CCRCC (Pearson r = -0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	MYH14 →	-1.034	-0.641	<.001	.002	3	3
OV	PPP2R5C →	-0.356	-0.524	.002	.003	3	3
CCRCC	ABHD4 →	-0.341	-0.634	.002	.003	3	2
CCRCC	CCND2 →	+0.504	+0.475	<.001	.006	3	2
CCRCC	OSER1 →	-0.309	-0.594	.002	.004	3	2
CCRCC	LDHC →	-0.366	-0.685	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001955 vs MYH14 — CCRCC

Explore this scatter interactively →