Blood vessel maturation

Across TCGA pan-cancer cohorts, RNA activity of the Blood vessel maturation pathway is associated with patient survival in 26 of 34 cancer lineages. Pathway activity is summarized from the expression of its 8 member genes.

The strongest signal is observed in uveal melanoma (UVM), where higher Blood vessel maturation pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SKCM and CHOL, show the opposite pattern, with higher activity associated with better survival.

UVM, KIRP, and SKCM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	III,IV	0.350	0.828	<.001	54	view →
KIRP	DFS	Tertile	III,IV	0.181	0.791	.003	44	view →
SKCM	OS	Quartile	All	0.492	0.259	<.001	38	view →
MESO	OS	Tertile	II,III,IV	0.278	0.532	.009	36	view →
LUSC	OS	Quartile	All	0.322	0.469	.011	36	view →
STAD	DFS	Quartile	All	0.525	0.842	.001	30	view →
LGG	DFS	Median	All	0.270	0.470	<.001	25	view →
OV	OS	Median	II,III,IV	0.806	0.877	.026	24	view →
CHOL	DFS	Median	All	0.672	0.175	.003	15	view →
HNSC	DFS	Tertile	III,IV	0.408	0.171	.017	14	view →
THCA	DFS	Tertile	IV	1.000	0.418	.008	14	view →
READ	DFS	Tertile	III,IV	0.299	0.722	.018	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

GO:0001955–UVM (DFS)

Open the UVM breakdown →