Blood vessel maturation

Across TCGA cell cohorts, RNA activity of the Blood vessel maturation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PACS2, ATP8A2, and MDM2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PACS2 grouped by Blood vessel maturation-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PACS2 →	+0.593	+1.156	<.001	<.001	3	5
BONE	ATP8A2 →	+1.021	+1.485	.004	.006	3	5
LUNG_SCLC	MDM2 →	+1.455	+1.519	<.001	<.001	3	5
LUNG_SCLC	ATXN7L3B →	+1.488	+1.258	<.001	.001	3	5
BONE	ZFAND5 →	+0.673	+1.496	.007	.004	3	5
LARGE_INTESTINE	CDKN1A →	+2.105	+1.116	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PACS2 by Blood vessel maturation activity — LARGE_INTESTINE

Explore this box plot interactively →