Positive regulation of cell-matrix adhesion

Across TCGA patient cohorts, RNA activity of the Positive regulation of cell-matrix adhesion pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM47, IGFBP7, and PRKG1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cell-matrix adhesion activity versus TMEM47 in COAD (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TMEM47 →	+1.006	+0.241	<.001	<.001	3	6
BRCA	IGFBP7 →	+0.692	+0.183	<.001	<.001	3	6
BRCA	PRKG1 →	+0.634	+0.161	<.001	<.001	3	6
PDAC	ZNF728 →	+0.468	+0.253	<.001	<.001	3	6
BRCA	SLC25A39 →	-0.610	-0.148	.004	.006	3	6
UCEC	MIR99AHG →	+0.851	+0.310	.002	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001954 vs TMEM47 — COAD

Explore this scatter interactively →