Positive regulation of cell-matrix adhesion

Across TCGA cell cohorts, RNA activity of the Positive regulation of cell-matrix adhesion pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPM1F, CRYBB1, and RAB43, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPM1F grouped by Positive regulation of cell-matrix adhesion-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PPM1F →	-0.302	-1.102	.002	.001	3	7
LUNG_NSCLC_LUSC	CRYBB1 →	-0.376	-1.813	.007	<.001	3	7
LUNG_SCLC	RAB43 →	-0.271	-1.053	.007	.005	3	7
CNS	CCR7 →	-0.446	-1.006	<.001	.002	3	7
OVARY	TRIM41 →	-0.274	-1.085	<.001	.003	3	6
BLOOD_Lymphoma	D2HGDH →	-0.380	-2.175	.001	.001	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPM1F by Positive regulation of cell-matrix adhesion activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →