Positive regulation of cell-matrix adhesion

Across TCGA cell cohorts, RNA activity of the Positive regulation of cell-matrix adhesion pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM114A1, MEPCE, and ESRRA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FAM114A1 grouped by Positive regulation of cell-matrix adhesion-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	FAM114A1 →	-1.255	-0.970	.002	.004	3	4
PANCREAS	MEPCE →	-0.772	-1.117	<.001	<.001	3	4
BONE	ESRRA →	-0.704	-1.677	.008	<.001	3	3
LUNG_NSCLC_LUSC	PDE4B →	-1.395	-1.348	<.001	<.001	3	3
PANCREAS	POP7 →	-0.724	-1.038	.005	.006	2	4
CNS	UBE2K →	-0.513	-1.048	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FAM114A1 by Positive regulation of cell-matrix adhesion activity — CNS

Explore this box plot interactively →