Negative regulation of cell-matrix adhesion

Across TCGA patient cohorts, RNA activity of the Negative regulation of cell-matrix adhesion pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DIRC3-AS1, FEZ1, and NPHP3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cell-matrix adhesion activity versus DIRC3-AS1 in LUAD (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	DIRC3-AS1 →	+0.111	+0.521	.008	.006	3	5
HNSC	FEZ1 →	+0.683	+0.522	.005	<.001	3	3
UCEC	NPHP3 →	+0.467	+0.912	<.001	.002	3	3
UCEC	EGFL8 →	+0.767	+0.960	<.001	.001	3	3
UCEC	MIR4768 →	+0.890	+0.728	.004	.007	3	3
OV	LAMA4 →	+1.162	+0.982	<.001	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001953 vs DIRC3-AS1 — LUAD

Explore this scatter interactively →