Postsynaptic membrane organization

Across TCGA patient cohorts, RNA activity of the Postsynaptic membrane organization pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MYL6B, CDH2, and ARFIP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Postsynaptic membrane organization activity versus MYL6B in HNSC (Pearson r = 0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MYL6B →	+1.441	+0.037	<.001	.005	3	6
UCEC	CDH2 →	+0.667	+0.048	<.001	<.001	3	5
GBM	ARFIP1 →	-0.236	-0.086	<.001	<.001	3	5
CCRCC	IKZF1 →	-0.251	-0.030	.001	<.001	3	5
BRCA	SNAP23 →	-0.192	-0.024	.007	<.001	3	5
HNSC	CAP2 →	+0.744	+0.033	<.001	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001941 vs MYL6B — HNSC

Explore this scatter interactively →