Postsynaptic membrane organization

Across TCGA pan-cancer cohorts, RNA activity of the Postsynaptic membrane organization pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 39 member genes.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher Postsynaptic membrane organization pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and LGG, show the opposite pattern, with higher activity associated with better survival.

READ, KICH, and COAD are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	OS	Median	II,III,IV	0.782	1.000	.001	44	view →
KICH	OS	Quartile	III,IV	0.177	0.805	.009	42	view →
COAD	OS	Tertile	III,IV	0.622	0.887	.005	38	view →
LUSC	DFS	Tertile	II,III,IV	0.487	0.648	.010	21	view →
LIHC	DFS	Quartile	All	0.445	0.581	.017	16	view →
HNSC	OS	Median	IV	0.478	0.331	.010	16	view →
SARC	DFS	Quartile	All	0.168	0.564	.006	13	view →
KIRC	DFS	Quartile	II,III,IV	0.565	0.802	.008	10	view →
LGG	OS	Median	All	0.543	0.384	.010	10	view →
CESC	OS	Tertile	All	0.738	0.844	.024	8	view →
SCLC	DFS	Median	II,III,IV	0.705	0.431	.021	8	view →
LUAD	DFS	Median	III,IV	0.465	0.168	.017	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:0001941–READ (OS)

Open the READ breakdown →