Postsynaptic membrane organization

Across TCGA patient cohorts, RNA activity of the Postsynaptic membrane organization pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRDV1, DNASE2, and PLCB1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Postsynaptic membrane organization activity versus TRDV1 in COAD (Pearson r = -0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TRDV1 →	-1.021	-0.831	.001	.001	3	4
LSCC	DNASE2 →	-0.415	-0.780	<.001	<.001	3	4
LUAD	PLCB1 →	+0.808	+0.594	<.001	.003	3	4
CCRCC	CD36 →	+0.860	+0.665	<.001	.003	3	4
CCRCC	NRARP →	+0.658	+0.660	<.001	<.001	3	4
BRCA	ICOS →	-0.707	-0.478	.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001941 vs TRDV1 — COAD

Explore this scatter interactively →