Postsynaptic membrane organization

Across TCGA cell cohorts, RNA activity of the Postsynaptic membrane organization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HEATR5B, TERF1, and UBR5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HEATR5B grouped by Postsynaptic membrane organization-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	HEATR5B →	-0.672	-0.366	<.001	.002	3	4
OVARY	TERF1 →	-0.575	-0.455	.004	.003	3	3
BLOOD_Lymphoma	UBR5 →	-1.310	-0.404	.001	.005	2	4
BLOOD_Lymphoma	RIDA →	-0.905	-0.391	.005	<.001	3	3
BLOOD_Lymphoma	VIRMA →	-0.732	-0.391	.004	<.001	3	3
BLOOD_Lymphoma	GKAP1 →	-1.173	-0.366	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HEATR5B by Postsynaptic membrane organization activity — BLOOD_Lymphoma

Explore this box plot interactively →