Postsynaptic membrane organization

Across TCGA cell cohorts, RNA activity of the Postsynaptic membrane organization pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRPS30, DHX32, and P2RY6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Postsynaptic membrane organization activity versus MRPS30 in LUNG_NSCLC_LUSC (Pearson r = 0.82).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MRPS30 →	+1.151	+0.434	.003	.001	3	4
LUNG_NSCLC_LUSC	DHX32 →	-1.364	-0.300	<.001	.003	3	4
BREAST	P2RY6 →	-1.750	-0.248	.008	.003	2	5
CNS	JAG2 →	+2.152	+0.348	.009	.003	3	3
BLOOD_Leukemia	OTUD5 →	+0.607	+0.695	.001	.007	3	3
BLOOD_Leukemia	OSBPL6 →	+1.697	+0.479	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001941 vs MRPS30 — LUNG_NSCLC_LUSC

Explore this scatter interactively →