Positive regulation of receptor recycling

Across TCGA patient cohorts, RNA activity of the Positive regulation of receptor recycling pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMBIM1, PTK2, and SAMD12, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of receptor recycling activity versus TMBIM1 in GBM (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TMBIM1 →	+0.404	+0.379	.002	<.001	3	4
COAD	PTK2 →	+0.381	+0.517	.001	.007	3	4
COAD	SAMD12 →	+0.255	+0.379	.008	.005	3	4
PDAC	PARP4 →	+0.455	+0.858	<.001	<.001	3	3
LUAD	TMEM59 →	+0.375	+0.531	.007	.005	3	3
PDAC	YPEL5 →	+0.263	+0.726	.007	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001921 vs TMBIM1 — GBM

Explore this scatter interactively →