Positive regulation of receptor recycling

Across TCGA cell cohorts, RNA activity of the Positive regulation of receptor recycling pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HIF1A, FLNB, and HEG1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HIF1A grouped by Positive regulation of receptor recycling-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	HIF1A →	+1.384	+0.340	.003	.004	3	3
BONE	FLNB →	+1.716	+0.186	.001	<.001	3	3
BONE	HEG1 →	+3.402	+0.213	<.001	.001	3	3
BONE	CYTH3 →	+1.659	+0.162	.001	.004	3	3
URINARY_TRACT	C8orf33 →	+0.517	+0.375	.003	.009	3	3
LARGE_INTESTINE	ERCC1 →	+0.701	+0.764	.009	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HIF1A by Positive regulation of receptor recycling activity — LIVER

Explore this box plot interactively →