Positive regulation of receptor recycling

Across TCGA cell cohorts, RNA activity of the Positive regulation of receptor recycling pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FZD3, C8orf33, and GPAA1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of receptor recycling activity versus FZD3 in LUNG_NSCLC_LUSC (Pearson r = 0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	FZD3 →	+1.837	+0.326	<.001	<.001	3	5
LUNG_NSCLC_LUSC	C8orf33 →	+1.199	+0.409	.008	<.001	3	5
OESOPHAGUS	GPAA1 →	+0.901	+0.345	.002	.001	3	5
URINARY_TRACT	ATAD2 →	+0.776	+0.212	.007	.005	2	6
BLOOD_Leukemia	BOP1 →	+0.684	+0.222	.002	.002	3	5
OESOPHAGUS	SCRIB →	+1.113	+0.295	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001921 vs FZD3 — LUNG_NSCLC_LUSC

Explore this scatter interactively →