Regulation of receptor recycling

Across TCGA patient cohorts, RNA activity of the Regulation of receptor recycling pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IPO7, SEH1L, and RPL5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of receptor recycling activity versus IPO7 in CCRCC (Pearson r = -0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	IPO7 →	-0.116	-0.029	<.001	<.001	3	5
GBM	SEH1L →	-0.240	-0.084	<.001	<.001	3	5
BRCA	RPL5 →	-0.277	-0.055	<.001	<.001	3	4
GBM	TCIM_S21 →	+0.594	+0.082	.003	.005	3	4
CCRCC	INPP5F_S1103 →	+0.191	+0.030	.002	<.001	3	4
OV	OBI1_S210 →	-0.955	-0.050	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001919 vs IPO7 — CCRCC

Explore this scatter interactively →