Negative regulation of T cell mediated cytotoxicity

Across TCGA cell cohorts, RNA activity of the Negative regulation of T cell mediated cytotoxicity pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RGPD2, HK2, and BCR, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of T cell mediated cytotoxicity activity versus RGPD2 in BLOOD_Leukemia (Pearson r = -0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RGPD2 →	-1.636	-0.428	<.001	.008	3	2
BLOOD_Lymphoma	HK2 →	-1.983	-0.300	.009	.007	3	2
BLOOD_Lymphoma	BCR →	-2.078	-0.245	.003	.005	3	2
LARGE_INTESTINE	ZDHHC11 →	+2.085	+0.420	.009	.008	3	2
BLOOD_Leukemia	HLA-B →	+2.194	+0.463	<.001	.004	3	1
BLOOD_Leukemia	NCKAP1 →	-1.732	-0.483	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001915 vs RGPD2 — BLOOD_Leukemia

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