Leukocyte mediated cytotoxicity

Across TCGA cell cohorts, RNA activity of the Leukocyte mediated cytotoxicity pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPAG8, AP3B2, and PPM1D, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SPAG8 grouped by Leukocyte mediated cytotoxicity-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	SPAG8 →	-0.527	-1.598	.003	.005	3	3
CNS	AP3B2 →	-1.626	-0.774	.002	.005	3	3
CNS	PPM1D →	-0.489	-0.706	.003	<.001	3	3
BREAST	NXPH4 →	+1.363	+0.787	.005	.001	3	3
CNS	FJX1 →	+1.733	+0.827	<.001	.009	3	3
CNS	RIPPLY3 →	-0.148	-0.950	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SPAG8 by Leukocyte mediated cytotoxicity activity — URINARY_TRACT

Explore this box plot interactively →