Tissue homeostasis

Across TCGA patient cohorts, RNA activity of the Tissue homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the ESCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NFATC2, FGD2, and GIMAP8, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tissue homeostasis activity versus NFATC2 in ESCA (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	NFATC2 →	+1.396	+0.047	<.001	<.001	3	33
SCLC	FGD2 →	+1.524	+0.040	<.001	<.001	3	33
SCLC	GIMAP8 →	+1.527	+0.057	<.001	<.001	3	33
CHOL	CALHM5 →	+0.903	+0.033	<.001	<.001	3	33
LAML	CALCRL →	+1.680	+0.020	<.001	<.001	3	33
CHOL	CSF2RB →	+1.990	+0.036	<.001	.002	2	33

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001894 vs NFATC2 — ESCA

Explore this scatter interactively →