Tissue homeostasis

Across TCGA patient cohorts, RNA activity of the Tissue homeostasis pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SNTB2_S222, SORBS1, and SYNPO, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tissue homeostasis activity versus SNTB2_S222 in GBM (Pearson r = 0.54).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SNTB2_S222 →	+0.839	+0.043	<.001	<.001	3	10
CCRCC	SORBS1 →	+0.800	+0.041	<.001	<.001	3	10
OV	SYNPO →	+0.476	+0.026	<.001	.008	3	10
OV	TAGLN →	+1.017	+0.052	.002	<.001	3	10
OV	TNS2 →	+0.573	+0.042	<.001	<.001	3	10
OV	TNS2_S120 →	+0.724	+0.027	<.001	.003	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001894 vs SNTB2_S222 — GBM

Explore this scatter interactively →