Tissue homeostasis

Across TCGA cell cohorts, RNA activity of the Tissue homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MCU, ANXA3, and PPP1R13L, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tissue homeostasis activity versus MCU in BONE (Pearson r = 0.79).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	MCU →	+1.064	+0.351	.006	.007	3	6
STOMACH	ANXA3 →	+3.973	+0.223	<.001	.001	3	6
BONE	PPP1R13L →	+1.936	+0.302	.001	.001	3	6
PANCREAS	DDX60 →	+2.424	+0.403	<.001	<.001	3	6
CNS	RASSF7 →	+1.288	+0.181	.003	<.001	3	5
STOMACH	MYL12B →	+1.417	+0.234	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001894 vs MCU — BONE

Explore this scatter interactively →