Maternal placenta development

Across TCGA cell cohorts, RNA activity of the Maternal placenta development pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTRH2, SCG2, and METTL2A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PTRH2 grouped by Maternal placenta development-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	PTRH2 →	+0.721	+1.182	.004	.004	3	4
LUNG_NSCLC_LUAD	SCG2 →	-2.096	-0.750	.003	.001	3	4
CNS	METTL2A →	+0.337	+0.898	.001	<.001	3	4
LUNG_NSCLC_LUSC	NMRAL1 →	+1.208	+1.213	.005	.009	3	3
KIDNEY	PSMD3 →	+0.885	+1.457	.009	<.001	3	3
KIDNEY	ZFP2 →	-0.436	-0.771	.004	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PTRH2 by Maternal placenta development activity — OESOPHAGUS

Explore this box plot interactively →