Placenta development

Across TCGA patient cohorts, RNA activity of the Placenta development pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PVR, PDRG1, and ST6GALNAC1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Placenta development activity versus PVR in PDAC (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PVR →	+0.549	+0.272	<.001	.001	3	3
PDAC	PDRG1 →	+0.392	+0.343	.001	.001	3	3
COAD	ST6GALNAC1 →	-1.109	-0.124	.003	.001	3	3
OV	LRG1 →	+1.681	+0.154	.003	.004	3	3
CCRCC	NR3C2 →	-0.879	-0.228	<.001	.001	3	3
CCRCC	KRT15 →	+0.472	+0.198	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001890 vs PVR — PDAC

Explore this scatter interactively →