Placenta development

Across TCGA pan-cancer cohorts, RNA activity of the Placenta development pathway differs between tumor and matched normal tissue in 11 of the 18 cancer types tested.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as KICH and KIRP, show the opposite pattern, with lower activity in tumor tissue.

HNSC, KICH, and KIRC show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
HNSC	Male	III,IV	+0.048	<.001	11	view →
KICH	All	III,IV	−0.044	<.001	10	view →
KIRC	Female	All	+0.033	<.001	10	view →
COAD	All	III,IV	+0.023	.004	6	view →
STAD	Male	II,III,IV	+0.054	<.001	4	view →
CHOL	All	All	+0.036	<.001	4	view →
KIRP	All	All	−0.019	<.001	4	view →
BRCA	Female	All	−0.011	.002	4	view →
PAAD	Female	All	+0.059	.026	2	view →
PRAD	All	All	−0.022	<.001	2	view →
LUSC	All	All	+0.019	<.001	2	view →

Pink = more active in tumor, green = less active in tumor. Showing the 11 strongest of 11 lineages.

GO:0001890–HNSC

Open the HNSC breakdown →