Placenta development

Across TCGA cell cohorts, RNA activity of the Placenta development pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GK5, HSD17B2, and BIN3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GK5 grouped by Placenta development-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	GK5 →	+1.299	+0.224	<.001	.006	3	4
LARGE_INTESTINE	HSD17B2 →	-1.301	-0.396	.005	.004	3	4
OVARY	BIN3 →	-0.511	-0.643	<.001	.001	3	3
LIVER	NEURL1B →	-2.064	-1.514	.004	.002	3	3
OESOPHAGUS	TAOK1 →	+1.164	+0.200	.003	.007	1	5
OVARY	HP1BP3 →	-0.665	-0.822	.004	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GK5 by Placenta development activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →