Endothelial cell morphogenesis

Across TCGA cell cohorts, RNA activity of the Endothelial cell morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PINK1, BRICD5, and ZDHHC2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PINK1 grouped by Endothelial cell morphogenesis-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PINK1 →	-1.306	-1.195	.008	.002	3	5
KIDNEY	BRICD5 →	+1.080	+1.420	.001	.001	3	5
STOMACH	ZDHHC2 →	-2.434	-1.237	.002	.005	3	4
STOMACH	ELK3 →	-1.330	-1.244	.002	<.001	3	4
OESOPHAGUS	KMT2B →	+0.896	+1.224	.005	.002	2	5
LUNG_SCLC	CIAPIN1 →	+0.612	+1.175	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PINK1 by Endothelial cell morphogenesis activity — STOMACH

Explore this box plot interactively →