Endothelial cell development

Across TCGA patient cohorts, RNA activity of the Endothelial cell development pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NID2, RSU1, and SYNPO, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endothelial cell development activity versus NID2 in COAD (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	NID2 →	+0.463	+0.034	<.001	<.001	3	10
COAD	RSU1 →	+0.489	+0.034	<.001	<.001	3	9
BRCA	SYNPO →	+0.392	+0.028	<.001	<.001	3	9
BRCA	GUCY1A1 →	+0.517	+0.044	<.001	<.001	3	9
UCEC	GUCY1B1 →	+0.476	+0.053	<.001	.004	3	9
COAD	PALM →	+0.569	+0.033	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001885 vs NID2 — COAD

Explore this scatter interactively →