Endothelial cell development

Across TCGA patient cohorts, RNA activity of the Endothelial cell development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FGF1, HECW2, and LINC00933, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endothelial cell development activity versus FGF1 in BRCA (Pearson r = -0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FGF1 →	+0.732	+0.153	.008	.006	3	4
LUAD	HECW2 →	+0.681	+0.170	<.001	<.001	3	3
LUAD	LINC00933 →	+0.199	+0.116	.008	.008	3	3
CCRCC	PCDH12 →	+0.474	+0.197	.005	.006	3	3
CCRCC	CD93 →	+0.407	+0.226	.005	.001	3	3
CCRCC	NTRK2 →	+0.960	+0.316	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001885 vs FGF1 — BRCA

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