Endothelial cell development

Across TCGA cell cohorts, RNA activity of the Endothelial cell development pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COMMD5, ARPC3, and ZNF165, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endothelial cell development activity versus COMMD5 in BLOOD_Lymphoma (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	COMMD5 →	+0.559	+0.186	.006	.005	3	5
LARGE_INTESTINE	ARPC3 →	+0.477	+0.314	.002	.001	3	5
LUNG_SCLC	ZNF165 →	+1.111	+0.261	.002	.003	3	5
PANCREAS	CD2AP →	+0.904	+0.332	<.001	<.001	3	5
BLOOD_Myeloma	SMOX →	-2.459	-0.265	<.001	.005	3	4
KIDNEY	LRRC8B →	+1.042	+0.271	.006	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001885 vs COMMD5 — BLOOD_Lymphoma

Explore this scatter interactively →