Response to yeast

Across TCGA cell cohorts, RNA activity of the Response to yeast pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPINK5, TRIM2, and IKBIP, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to yeast activity versus SPINK5 in OESOPHAGUS (Pearson r = -0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SPINK5 →	-2.132	-1.470	.009	.001	3	3
OVARY	TRIM2 →	-2.204	-0.968	<.001	.005	3	3
URINARY_TRACT	IKBIP →	+2.123	+1.758	.002	<.001	3	3
BLOOD_Leukemia	GOLIM4 →	-2.293	-0.752	.001	.006	3	3
OESOPHAGUS	SLC35E4 →	+1.464	+1.588	.005	.002	3	2
OESOPHAGUS	CBX7 →	+1.137	+1.262	.003	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001878 vs SPINK5 — OESOPHAGUS

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