Neural tube formation

Across TCGA patient cohorts, RNA activity of the Neural tube formation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FSTL1, VCAN, and TP53BP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neural tube formation activity versus FSTL1 in OV (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FSTL1 →	+0.955	+0.049	<.001	<.001	3	6
BRCA	VCAN →	+0.617	+0.025	<.001	<.001	3	6
LUAD	TP53BP1 →	+0.266	+0.027	<.001	<.001	3	5
HNSC	ADNP →	+0.245	+0.041	<.001	<.001	3	5
OV	THBS3 →	+0.613	+0.050	.001	<.001	3	5
HNSC	DTX3 →	+0.559	+0.048	<.001	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001841 vs FSTL1 — OV

Explore this scatter interactively →