Neural tube formation

Across TCGA patient cohorts, RNA activity of the Neural tube formation pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARL5C, RNA5SP69, and C8B, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neural tube formation activity versus ARL5C in OV (Pearson r = -0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ARL5C →	-0.028	-0.472	.008	.008	3	2
OV	RNA5SP69 →	+0.257	+0.881	.002	<.001	3	2
OV	C8B →	-0.058	-0.643	.004	<.001	3	2
OV	SLC25A53P1 →	-0.153	-0.459	.001	.004	3	2
OV	NCOA4 →	+0.581	+0.603	<.001	.005	3	2
OV	H2AC12 →	-0.520	-0.559	.005	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001841 vs ARL5C — OV

Explore this scatter interactively →