Neural tube formation

Across TCGA patient cohorts, RNA activity of the Neural tube formation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AZU1, CAMP, and CAVIN2_S370, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neural tube formation activity versus AZU1 in HNSC (Pearson r = -0.10).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	AZU1 →	-0.787	-1.381	<.001	<.001	3	2
PDAC	CAMP →	-1.275	-0.981	<.001	<.001	3	2
PDAC	CAVIN2_S370 →	+0.937	+1.173	<.001	<.001	3	2
PDAC	ELANE →	-0.685	-0.625	.001	.001	3	2
PDAC	FCN1 →	-0.734	-0.804	<.001	<.001	3	2
PDAC	ANK1_S1686 →	-0.715	-0.999	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001841 vs AZU1 — HNSC

Explore this scatter interactively →