Neural tube formation

Across TCGA cell cohorts, RNA activity of the Neural tube formation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COX7A2, ANK2, and HOXC10, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, COX7A2 grouped by Neural tube formation-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	COX7A2 →	+1.027	+1.237	.002	<.001	3	4
SKIN	ANK2 →	-1.180	-0.826	<.001	<.001	3	4
STOMACH	HOXC10 →	+3.062	+0.923	<.001	.007	3	3
LARGE_INTESTINE	SAT1 →	+1.278	+1.057	<.001	.003	3	3
LARGE_INTESTINE	ATP6V1C2 →	+1.582	+1.079	<.001	<.001	3	3
SKIN	PBXIP1 →	-0.988	-1.007	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

COX7A2 by Neural tube formation activity — LARGE_INTESTINE

Explore this box plot interactively →