Neural tube formation

Across TCGA cell cohorts, RNA activity of the Neural tube formation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are B3GALT6, MTHFR, and PLEKHM2, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neural tube formation activity versus B3GALT6 in STOMACH (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	B3GALT6 →	+1.005	+0.097	<.001	.001	3	13
BLOOD_Leukemia	MTHFR →	+1.048	+0.041	<.001	<.001	3	13
STOMACH	PLEKHM2 →	+1.269	+0.103	<.001	<.001	3	12
BLOOD_Leukemia	SKI →	+1.364	+0.068	<.001	<.001	3	12
STOMACH	CUL7 →	+0.932	+0.083	<.001	.002	3	12
SOFT_TISSUE	PEX14 →	+0.760	+0.072	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001841 vs B3GALT6 — STOMACH

Explore this scatter interactively →