Epithelial to mesenchymal transition

Across TCGA cell cohorts, RNA activity of the Epithelial to mesenchymal transition pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LNPK, S100A4, and C4orf36, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Epithelial to mesenchymal transition activity versus LNPK in BREAST (Pearson r = -0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	LNPK →	-0.706	-0.207	.005	.005	2	8
PANCREAS	S100A4 →	+4.444	+0.353	.003	<.001	3	6
LUNG_NSCLC_LUSC	C4orf36 →	+1.126	+0.300	<.001	.001	3	5
LUNG_NSCLC_LUAD	BIK →	+1.503	+0.221	<.001	<.001	3	5
LUNG_NSCLC_LUSC	MFNG →	+1.646	+0.294	.002	.001	3	4
LUNG_NSCLC_LUSC	KLK10 →	+5.366	+0.473	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001837 vs LNPK — BREAST

Explore this scatter interactively →