Inner cell mass cell differentiation

Across TCGA cell cohorts, RNA activity of the Inner cell mass cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD47, MBNL1, and COPS5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CD47 grouped by Inner cell mass cell differentiation-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CD47 →	-1.625	-0.909	.003	<.001	3	4
SOFT_TISSUE	MBNL1 →	-1.031	-1.440	.003	.007	3	3
BLOOD_Lymphoma	COPS5 →	-0.702	-0.394	.004	.006	3	3
URINARY_TRACT	SPEN →	+0.767	+1.413	.007	.006	3	3
BLOOD_Lymphoma	LSM10 →	-0.992	-0.387	.004	.008	3	3
LARGE_INTESTINE	APMAP →	+0.657	+0.789	.005	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CD47 by Inner cell mass cell differentiation activity — STOMACH

Explore this box plot interactively →