Blastocyst formation

Across TCGA cell cohorts, RNA activity of the Blastocyst formation pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PGAM5, EPHA1, and MRPS27, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Blastocyst formation activity versus PGAM5 in LIVER (Pearson r = 0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	PGAM5 →	+1.261	+1.584	.004	.001	3	6
URINARY_TRACT	EPHA1 →	-4.475	-1.645	<.001	.003	3	6
PANCREAS	MRPS27 →	+0.763	+1.107	.003	.005	2	7
LUNG_SCLC	TMEM165 →	-0.653	-0.824	<.001	.002	3	5
URINARY_TRACT	CDS1 →	-3.130	-1.555	<.001	.004	3	5
URINARY_TRACT	SPINT1 →	-4.945	-2.026	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001825 vs PGAM5 — LIVER

Explore this scatter interactively →