Mesonephros development

Across TCGA patient cohorts, RNA activity of the Mesonephros development pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TAP1, STAT1, and TAPBP, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mesonephros development activity versus TAP1 in CCRCC (Pearson r = -0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TAP1 →	-0.509	-0.037	<.001	<.001	3	9
LSCC	STAT1 →	-0.619	-0.037	<.001	.001	3	8
CCRCC	TAPBP →	-0.525	-0.035	<.001	<.001	3	8
OV	LARP1 →	-0.272	-0.034	.002	.001	3	7
LSCC	PSMB6 →	+0.397	+0.040	<.001	<.001	3	7
LSCC	ARVCF_T642 →	+0.739	+0.042	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001823 vs TAP1 — CCRCC

Explore this scatter interactively →