Serotonin secretion

Across TCGA cell cohorts, RNA activity of the Serotonin secretion pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LYRM2, XRCC2, and ULK3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LYRM2 grouped by Serotonin secretion-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	LYRM2 →	-0.744	-0.957	<.001	<.001	3	5
CNS	XRCC2 →	-0.902	-1.340	<.001	<.001	3	4
SKIN	ULK3 →	+0.710	+1.023	<.001	<.001	3	4
BREAST	SMIM7 →	-0.561	-1.085	.003	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	SCNN1A →	+2.624	+1.379	.003	.001	3	3
OESOPHAGUS	SHLD3 →	-0.639	-1.630	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LYRM2 by Serotonin secretion activity — BREAST

Explore this box plot interactively →