Immunological synapse formation

Across TCGA patient cohorts, RNA activity of the Immunological synapse formation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCSD1, SAMSN1_S107, and SASH3, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Immunological synapse formation activity versus RCSD1 in HNSC (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RCSD1 →	+0.639	+0.133	<.001	<.001	3	10
GBM	SAMSN1_S107 →	+0.807	+0.120	<.001	<.001	3	10
GBM	SASH3 →	+0.557	+0.115	<.001	<.001	3	10
LSCC	SEPTIN6 →	+0.578	+0.188	<.001	<.001	3	10
GBM	SKAP2 →	+0.740	+0.108	<.001	<.001	3	10
OV	STAT5A →	+0.457	+0.077	.002	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001771 vs RCSD1 — HNSC

Explore this scatter interactively →