Neuron migration

Across TCGA cell cohorts, RNA activity of the Neuron migration pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NPM3, AP5S1, and NCOA6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NPM3 grouped by Neuron migration-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	NPM3 →	-1.276	-0.256	.001	.001	3	5
LUNG_SCLC	AP5S1 →	+0.993	+0.265	.002	<.001	3	4
LUNG_SCLC	NCOA6 →	+0.972	+0.313	<.001	<.001	3	4
SOFT_TISSUE	CCDC78 →	-2.033	-0.350	.002	<.001	3	4
STOMACH	ATP6AP2 →	+1.024	+0.230	.001	.001	3	4
BLOOD_Leukemia	RPL27 →	-0.449	-0.642	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NPM3 by Neuron migration activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →