Neuron migration

Across TCGA cell cohorts, RNA activity of the Neuron migration pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OXSM, URI1, and RDH12, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuron migration activity versus OXSM in SKIN (Pearson r = -0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OXSM →	-0.808	-0.273	.004	.007	3	4
BLOOD_Leukemia	URI1 →	-0.550	-0.305	.003	.006	3	3
BLOOD_Leukemia	RDH12 →	-0.117	-0.220	.003	.001	3	3
URINARY_TRACT	MRPS25 →	-1.076	-0.362	.005	.002	3	3
URINARY_TRACT	CAPN7 →	-1.165	-0.536	<.001	<.001	3	3
URINARY_TRACT	GOLGA4 →	-0.543	-0.404	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001764 vs OXSM — SKIN

Explore this scatter interactively →