Morphogenesis of a branching structure

Across TCGA patient cohorts, RNA activity of the Morphogenesis of a branching structure pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PRKG1, ARHGEF17, and RSU1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Morphogenesis of a branching structure activity versus PRKG1 in OV (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PRKG1 →	+0.700	+0.041	<.001	<.001	3	9
CCRCC	ARHGEF17 →	+0.441	+0.043	<.001	<.001	3	9
OV	RSU1 →	+0.388	+0.054	<.001	<.001	3	8
BRCA	SEPTIN11 →	+0.425	+0.038	<.001	<.001	3	8
BRCA	TLN2 →	+0.724	+0.044	<.001	<.001	3	8
UCEC	TPM1 →	+0.661	+0.039	.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001763 vs PRKG1 — OV

Explore this scatter interactively →