Morphogenesis of a branching structure

Across TCGA patient cohorts, RNA activity of the Morphogenesis of a branching structure pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NME9, HEXIM1, and PIK3R2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Morphogenesis of a branching structure activity versus NME9 in BRCA (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NME9 →	+0.441	+0.889	<.001	<.001	3	3
BRCA	HEXIM1 →	+1.276	+1.000	<.001	<.001	3	3
COAD	PIK3R2 →	+0.036	+0.356	.004	<.001	3	2
BRCA	ZNF767P →	+0.708	+0.867	.002	<.001	3	2
COAD	GEMIN7 →	+0.220	+0.356	.003	.003	3	2
COAD	HPD →	+0.308	+0.540	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001763 vs NME9 — BRCA

Explore this scatter interactively →