Morphogenesis of a branching structure

Across TCGA patient cohorts, RNA activity of the Morphogenesis of a branching structure pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RMC1, RPUSD3, and RUFY1_T74, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Morphogenesis of a branching structure activity versus RMC1 in BRCA (Pearson r = -0.08).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RMC1 →	-0.380	-1.118	<.001	<.001	3	1
BRCA	RPUSD3 →	-0.639	-0.858	<.001	<.001	3	1
BRCA	RUFY1_T74 →	-0.504	-0.778	.001	<.001	3	1
BRCA	RUNX3_S214 →	-1.165	-1.233	.001	<.001	3	1
BRCA	SCUBE2 →	+2.077	+1.093	<.001	<.001	3	1
BRCA	SERAC1 →	-0.620	-0.545	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001763 vs RMC1 — BRCA

Explore this scatter interactively →